<p>Dihydrofolate reductase (DHFR) catalyses the NADPH-dependent reduction of dihydrofolate to tetrahydrofolate, an essential step in <i>de novo</i> synthesis both of glycine and of purines and deoxythymidine phosphate (the precursors of DNA synthesis) [<cite idref="PUB00005107"/>], and important also in the conversion of deoxyuridine monophosphate to deoxythymidine monophosphate.</p><p>This entry represents a structural domain found in dihydrofolate reductases, as well as in riboflavin biosynthesis proteins (usually as a C-terminal domain) and related enzymes.</p> Dihydrofolate reductase-like domain